Adipocytes regulate the normal lipid metabolism of the body
Excessive fat intake can lead to an unhealthy metabolic state and obesity, which can have the negative effect of increasing the risk of diabetes, hypertension and many other diseases.
Liposuction and other methods of removing subcutaneous fat can be detrimental to human health and it is not yet possible to remove visceral fat.
A team of researchers at the University of Cambridge has used nanomaterials to target fat removal while also improving fat metabolism.
The results of the study on subcutaneous and visceral fat were recently published in Biomaterials and Nature Nanotechnology.
The researchers found that adipose tissue contains a large amount of negatively charged extracellular matrix to support and anchor adipocytes.
They tried injecting the positively charged nanomaterial P-G3 (originally used to reduce inflammation) into obese mice and
They found that P-G3 rapidly distributed to all parts of the adipose tissue with good targeting effects.
Further studies showed that P-G3 also promoted new adipocyte formation and blocked the unhealthy lipid storage process of adipocytes.
Obese mice injected with P-G3 lost weight and had a healthier metabolic state.
They had a higher percentage of healthy, young, small adipocytes, just like newborns or athletes.
This result was also validated in human adipose tissue, which has a great potential for transformation.